Generalized Anxiety Disorder (GAD)

Excessive anxiety and worry (apprehensive expectation), occurring more days than not for at least 6 months, about a number of activities.

Etiology (Biopsychosocial Model)

Biological: GABA and serotonin imbalances; moderate heritability.

Psychological: Perfectionism, intolerance of uncertainty.

Social: Ongoing stressors, adverse early experiences.

Symptoms & Diagnosis (Mnemonic: WATCHERS)

W - Worry (excessive and uncontrollable)

A - Anxiety more days than not

T - Tension in muscles

C - Concentration difficulties

H - Hypervigilance/irritability

E - Easily fatigued

R - Restlessness

S - Sleep disturbances

Treatment

CBT: CBT with worry exposure and cognitive restructuring.

Pharmacotherapy: SSRIs, SNRIs (e.g., paroxetine, venlafaxine).

Mindfulness: Mindfulness-Based Stress Reduction (MBSR).

Info

DSM-5-TR Code

F41.1

Prevalence

U.S. adults: 2.9%; more common in females (2:1).